Continue to access RSC content when you are not at your institution. Follow our step-by-step guide. Screening all existing and new commercial chemicals using computational models is a promising alternative to economically and ethically unviable animal tests. High throughput screening HTS assays and quantitative structure—activity relationships QSARs developed to assess chemical exposure, hazard and risk are a testament to the shift toward cost-effective strategies to protect human and environmental health. While existing computational tools can be used to screen chemicals for toxic endpoints, their utility in informing design of safer chemicals is limited. Rational design of chemicals with minimal biological activity and optimal functional efficacy is the foundational principle of green chemistry; yet, it is also the least-developed field of this discipline. This paper outlines development of a computational framework for designing commercial chemicals, while considering both their biological activity and intended function. The approach resembles computational drug discovery, applied to systematically design out target-specific toxicities utilizing prior knowledge of molecular initiating events MIE in adverse outcomes pathways AOP. Statistical free energy perturbation calculations are employed to demonstrate this approach for organophosphate flame retardants, a prominent class of chemicals of concern. This framework promises a strategy for safer chemical design that allows the practitioner to systematically weigh chemical drivers of toxicity, metabolism and functionality to determine trade-offs and optimal solutions to existing toxic chemicals.
Houston hotels near Discovery Green
The intentions and goals for the workshop are described at the end of this web page. A summary and conclusions of the workshop will be published in a white paper in Program and participant list:. Successful examples of working at the interface,bringing together biologists, engineers, computational scientists and biochemists for creating new imaging approaches for biological inquiry.
Defining the computational challenges that must be solved to realize the potential of the data flood. Invited trainees will be asked to bring a poster about their research, highlighting the interdisciplinary aspects.
The Houston Active Dogs Meetup Group is open for active, non-aggressive, well-socialized dogs of all ages and breeds. HAD Members enjoy meeting and getting together with their social canine companions! We are dedicated to the on-going well-being of our canine companions through socialization and recreation. There are many great rescues and shelters in Houston. Some work with any mixed breed dog while others may focus on specific breeds. Believe it or not, there are LOTS of purebred dogs that end up in shelters and rescues.
My favorite local shelter is Friends for Life located in the Heights. While they typically do not take owner surrenders they are a no-kill shelter with a focus on pulling animals from other area shelters that may be listed for euthanasia based on their breed, time at the shelter, medical condition, undesirable behavior, etc. Parking: Parking is limited but there are several garages nearby where you can pay to park.
Those that live close by, are encouraged to park at distant lots or neighborhoods and walk or ride bikes to the festival. Furry friends from every corner of the city and their humans will be welcomed into our doggy haven in downtown Houston. Thanks to the Puptopia organizers for setting up this HAD discount! Memory-making experiences abound – Puptopia Festival has something for every pup and their doting parent.
Houstonians march for Vanessa Guillen to City Hall
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Ice skating at Discovery Green is returning November 24! Wheelchairs on ICE If you are a non-motorized wheelchair user, you are welcome to enjoy the rink in your own wheelchair. You must be accompanied by a responsible adult at all times while on The ICE. Motorized wheelchairs are not permitted on The ICE.
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Discovery green events in Houston, TX
Gallery Speed Dating in June: Part Two Houston’s Aurora Picture Show is hosting a FREE screening and concert at Discovery Green on Saturday, June
Our hotel in Downtown Houston has everything you need to stay rested and productive during your stay. Recharge in our hotel rooms and suites with free Wi-Fi, ergonomic workspaces, and plush Marriott bedding. Maintain your active lifestyle at our hour fitness center or enjoy outdoor activities at Discovery Green. During your stay, enjoy easy access to attractions like George R. Our stylish event venues are also a great choice for your upcoming meeting or special occasion.
Hear from our guests about their stay from confirmed guest reviews. Host your upcoming meeting in one of our two versatile event venues with 1, sq.
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Still plenty of fun left at The ICE at Discovery Green
Sunday, February 10, by Houstonfirst Staff. So, now is the time to make those reservations. Restaurants at Avenida Houston and downtown have sweetheart menu items that will melt hearts and save money. About Us. Discovery Green. George R.
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The Discovery Talkshow with Hafsah Dabiri – Let’s Reflect on 2019
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Eventbrite – Hafsah Dabiri presents The Discovery Talkshow with Hafsah Dabiri – Let’s Reflect Single Muslim Professionals Speed Dating (Ages ) tickets.
Malcolm Jenkins sees historically significant opportunities before him with both the contending New Orleans Saints and with a racial justice movement that has gathered burgeoning momentum in recent months. With a total of 73 signatories, the new letter has more support than a similar letter released in , in which 50 of the nation’s senior Republican National Security officials warned that then-candidate Trump “would be the most reckless president in American history.
Bush, George W. McMaster, and former Defense Secretary James Mattis, who all served in, and were ousted from, the Trump administration. Peter Feaver, who served on the National Security Council under the Clinton and Bush administrations, told the Times that “letters like this have some unintended consequences. Trump was able to fund-raise off the letter and buy himself some anti-establishment street cred. His team even thought the letters were a net plus for him.
More stories from theweek. Surveillance footage of New England Patriots owner Robert Kraft at a massage parlour included in a lawsuit alleging he and others solicited prostitution will not be included in evidence after a Florida appeals court ruled it violated his rights. The Florida District Court of Appeals upheld a decision by a trial court to suppress the video, ruling the methods used violated the defendant’s Fourth Amendment rights against illegal search and seizures.
A Swiss court has placed the transfer, which took place in , under investigation for alleged money-laundering. Juan Carlos has not spoken publicly about the transfer but the Telegraph has seen a document from the Geneva investigation in which he also claims it was a gift he had no intention of seeking back.
In her interview with the BBC, Ms zu Sayn-Wittgenstein said that in Juan Carlos had in fact demanded that she return the sum – but she put it down to him being angry that she did not wish to resume a relationship she said had ceased to be romantic in
Ice Skating at Discovery Green
Below is a running list of events that have either been canceled or postponed. We will update the list as more information becomes available. Please check with the organizations for the most up-to-date information. By Eric Sandler. Movie Review. By Alex Bentley.
As the city is enforcing stricter guidelines on social distancing, Houstonians are looking for new ways to stay busy. Businesses are beginning to move online, offering more virtual experiences to consumers. From shopping, zoo visits and even virtual wine tasting, here are seven things you can do from home. The future of retail shopping is here! This is a highly interactive experience where you can FaceTime the shop during business hours. Each weekday at a.
The Houston Zoo is also sharing videos, adorable photos, and inviting fans to share with them on what they would like to see while they practice social distancing. The zoo also has several live web cameras so folks can check on their favorite animal any time of day. We want to hear from all our amazingly-talented musicians and thespians in Klein. While we’re out of school, use this flipgrid to upload videos of yourself practicing, singing, performing, reading poetry, basically anything of you performing.
We want to showcase you! So, Klein.